The objective of this study was to characterize these musculoskeletal manifestations and to assess their functional impact. Material and Methods: Individuals fulfilling ACR/EULAR 2013 classification criteria for SSc were consecutively included. by telephone to address encountered problems. The subjects used an exercise diary to document compliance. Patients were evaluated at baseline, 3 months (period without treatment), 6 months (at NMS-859 the end of the treatment after 3 months of treatment) and 9 weeks (follow-up). The subjects were evaluated with The Short Form Health Survey, Scleroderma Health Assessment Questionnaire, revised Rodnan skin score, Abilhand-SSc, Mouth Handicap in Systemic Sclerosis Level and mouth opening in millimeters. At the end of the study an individual qualitative interview is definitely planned. Results: At present, 7 individuals (Therabite n=4, mouth-stretching exercises n=3) were included and recruitment is definitely ongoing. 7 individuals completed their 3 months of exercises and increase of oral aperture is observed NMS-859 in all individuals in both organizations. In the Therabite group, after 3 months of exercise, increase of oral aperture was 10, 12, 10, and 2 mm. In Spp1 the mouth-stretching exercise group the NMS-859 increase of oral aperture was 9, 9 and 4 mm after 3 months. The compliance, measured as the percentage of carried out exercises relative to the planned quantity of exercises was 48,5%, 97,4%, 84,5% and 64,4% in the Therabite group and 98,9%, 95,2% and 68,3% in the mouth-stretching exercise group. Conclusions: An increase of oral aperture is observed in all individuals after 3 months of exercising with the Therabite device as well as after mouth-stretching exercises. No obvious variations are observed between both organizations, but the study was not designed nor powered for this. Remarkably, a high compliance for the treatment regime was observed in most individuals. P.270 Preliminary Data of an Intensive Physiotherapy Programme for Individuals with Systemic Sclerosis – Single-Center Controlled Study NMS-859 M. Spiritovic 1,2, H. Smucrova1, S. Oreska1, H. Storkanova1, P. Cesak2, A. Rathouska1, O. Ruzickova1, H. Mann1, K. Pavelka1, L. Senolt1, J. Vencovsky1, R. Becvar1, M. Tomcik1 1 Institute of Rheumatology, Division of Rheumatology, 1st Faculty of Medicine, Charles University or college, Prague, CZECH REPUBLIC, 2 Faculty of Physical Education and Sport, Charles University or college, Prague, CZECH REPUBLIC Intro: Pores and skin and musculoskeletal involvement in systemic sclerosis (SSc) prospects to disability and reduced quality of life. Evidence of nonpharmacologic treatment in SSc is limited due to the heterogeneity of the analyzed interventions and results. Study goals were to evaluate the effect of our physiotherapy programme on function of hands/face and quality of life. Material and Methods: All individuals had skin involvement of hands/mouth and fulfilled ACR/EULAR 2013 criteria. Both organizations received instructional materials for home exercise, however, only treatment group underwent the physiotherapy system. At weeks 0,3,6,12 all individuals were assessed by a physician (physical exam, mRSS-Modified Rodnans pores and skin score, EUSTAR SSc activity score, Medsger SSc severity score), and a physiotherapist blinded to treatment [validated measurements (dFTP-delta finger to palm, inter-incisor/inter-lip distance, hold strength using Baseline dynamometer); checks (HAMIS)], individuals filled NMS-859 out patient reported results/questionnaires (CHFS, MHISS, HAQ, SHAQ, SF-36) and offered blood for routine laboratory analysis and biobanking. Normality of data was tested, inter-group analysis was performed with 2-way ANOVA, and intra-group analysis by Friedmanns test with Dunns post hoc test. Results: 25 SSc individuals (22 female/3 male, 14 limited cutaneous (lc)SSc/11 diffuse cutaneous (dc)SSc, median of age 54.0 and disease duration 7.0 years, mRSS 12) were recruited into the intervention group (IG) and 29 patients into the control group (CG) (25 female/4 male, 16 lcSSc/13 dcSSc, median of age 49.0 and disease duration 5.0 years, mRSS 11). Compared to observed statistically significant deterioration in CG over the period of m0-m6, we found statistically significant improvement in dFTP, grip strength, HAMIS, inter-incisor and inter-lip distance. Only numerical improvement in IG compared to numerical deterioration in CG, which have not reached statistical significance, were observed in patient reported results (CHFS, MHISS, HAQ, SHAQ, SF-36). Conclusions: Physiotherapy system from our study led to a significant improvement in monitored parameters, which was clinically meaningful in a substantial proportion of individuals, and prevented the natural course of progressive deterioration of function of hands/mouth (observed in the control group). P.271 Significance of Combined ANTI-CCP Antibodies and Rheumatoid Factor in a New Zealand Cohort of Individuals with Systemic Sclerosis K. Solanki 1,2, S. Kamalaksha2, D.H.N White colored 1,2 1 Waikato Clinical School, University or college of Auckland, Hamilton, NEW ZEALAND, 2 Waikato DHB Hospital, Hamilton, NEW ZEALAND Intro: Musculoskeletal.